Fabrication and Characterization of Efficient Resin of Schiff base as Active Antimicrobial Agent

Document Type : Research Article


1 Dr. M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro76080, Pakistan

2 Applied Chemistry and Chemical Engineering, Rajshahi University, Bangladesh

3 National Centre of Excellence in Analytical Chemistry University of Sindh, Jamshoro, 76080, Pakistan

4 Institute of Biochemistry, University of Sindh, Jamshoro76080, Pakistan



In this study, formaldehyde (HCHO) and bis(2-Hydroxy-1-napthaldehyde)-o-phenylenediamine (BHNPhen) are heated to 120–130 °C for one to two hours in order to develop an effective antibacterial resin. Polymethylene bis(2-hydroxy-1-napthaldehyde)-o-phenylenediamine (PMBHNPhen), the resultant Schiff base, showed remarkable antibacterial qualities. Compounds consisting of a primary amine and a carbonyl molecule, which produce a chemical structure with an azomethine group (-HC=N-p), are referred to as "Schiff bases" by Hugo Schiff. The combination of Schiff bases and metal ions can lead to improvements in coordination and chemistry. The synthesized material was characterized by means of CHNS, FTIR, UV-visible spectroscopy, and SEM. analyses. The C.H.N. analytical results showed that the estimated values agreed well with the results, and the FTIR spectrum showed absorption bands at 1615cm-1 and 1620cm-1. A UV-visible spectroscopy investigation revealed polymerization-related changes in the absorption spectra. Significant antibacterial action was demonstrated by the synthesized Schiff base and resin against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. This work highlights the potential uses of Schiff base resin in biomedical interventions and advances the development of antibacterial materials.


Main Subjects