Document Type : Research Article
Authors
1
Department of Chemistry, Faculty of Physical Science, Ahmadu Bello University, Zaria Nigeria
2
Chemistry Department, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria
10.22034/jchemlett.2024.423104.1142
Abstract
Over time, microbial resistance to antimicrobial drugs has gradually raised and is therefore a considerable threat to public health. To tackle the menace of multi-resistant microbial activities which pose challenges to scientist, Iron oxide nanoparticles (Fe2O3 NPs) due to their importance in medicinal chemistry been known to exhibit antimicrobial activities against some microbes was synthesized using Funaria hygrometrica to investigate its antimicrobial activities against some selected microbes and then compared with two standard drugs ciprofloxacin and Terbinafine. Funaria hygrometrica, a commonly found moss species, was employed as a natural source of reducing, capping, and stabilizing agents for the synthesis of 〖"Fe" 〗_"2" "O" _"3" nanoparticles by co-precipitation method. The synthesized 〖"Fe" 〗_"2" "O" _"3" nanoparticles were characterized using techniques such as UV-spectrophotometer with a peak appearing at 335.00 ± 0.877 nm to indicate the band gap for synthesized iron from the Funaria hygrometrica, X-ray diffraction (XRD), with spectrum characteristics diffraction peaks at two-theta angles of 24.1o, 33.1o, 35.61o, 39.3o, 40.8o, 43.5o, 49.4o, 54.0o, 57.6o, 62.4o, 63.96o, and 71.91o, which conformed with haematite (Fe2O3), Scanning Electron micrograph/Energy Dispersive Xray (SEM/EDX) Spectroscopy which revealed its morphology of heterogenous dark surface with the elemental composition of 76.86% Fe and 23.14% O. Also, nanoparticles' diameter and structure were determined from Transmission Electron Micrograph (TEM) of 〖"Fe" 〗_"2" "O" _"3" nanoparticle to be 63.142 ± 16.633 nm, hexagonal crystal system, and roughly spherical. The synthesized Fe2O3 nanoparticles were screened against some selected microbes to determine its Zone of Inhibition (ZOI), Minimum Inhibitory Concentration (MIC) at 100 mg/L doses to inhibit the growth of Escherichia coli bacteria and Aspergillus flavus, Trichophyton mentagrophyte fungi and the Minimum Bactericidal and Fungicidal concentration (MBC/MFC) which completely inactivating Salmonella typhi at a dose of 100 mg/L.
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