Synthesis and characterization of Gabapentin-Zn2 Al-LDH nanohybrid and investigation of its drug release and biocompatibility properties on a laboratory scale.

Document Type : Research Article

Authors

1 Department of Chemistry, Bonab Branch, Islamic Azad University, Bonab, Iran

2 Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran

10.22034/jchemlett.2024.442139.1157

Abstract

Due to their high biocompatibility, Layered Double Hydroxides can be used as hosts in drug delivery systems. In Layered Double Hydroxide-drug hybrids, medicinal properties including stability in the physiological environment of the Body are investigated. The current research work is the synthesis and characterization of a new hybrid of LDH, which forms the nanocomposite of Gabapentin-Zn2Al-LDH. Gabapentin was selected as a drug model and intercalated in Zn2Al-LDH layers by co-precipitation method under a nitrogen atmosphere. To determine the structural characteristics of the Gabapentin-Zn2Al-LDH nanohybrid, the structure of Gabapentin-Zn2Al-LDH was investigated under X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. The size of nanohybrid particles in three dimensions X, Y, and Z was reported as 72, 43, and 58 nm, respectively. Finally, to evaluate biocompatibility and drug release properties, drug delivery and MTT assay tests for biocompatibility were performed. and acceptable results were obtained.

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